Esophageal surgery is a specialized procedure used to treat conditions such as cancer, obstruction, and severe reflux; however, it carries potential complications that may impact patient safety. Recognizing these complications is crucial for early detection and prompt intervention, which enhances treatment success and reduces health risks. Consistent medical care and diligent postoperative follow-up play a vital role in minimizing esophageal surgery complications and facilitating optimal recovery.
When is esophageal surgery performed?
Esophageal surgery is performed when non-surgical treatments fail to address serious issues that affect esophageal function or cause health-threatening complications. The primary goal of surgery is to restore the normal passage of food and improve patients’ quality of life.
The most common reasons for surgery
- Cancer: Esophageal cancer is one of the most common reasons for removing part or all of the esophagus to remove the tumor and limit its spread.
- Severe gastroesophageal reflux: In cases that don’t respond to medication and cause repeated damage to the esophagus, surgery is performed to strengthen the valve between the stomach and esophagus, thereby preventing acid reflux.
- Swallowing disorders: Narrowing or paralysis of the esophagus can make swallowing difficult and may require surgical intervention to improve passage.
- Complex hiatal hernia: When part of the stomach protrudes through the diaphragm in a way that causes severe symptoms or complications, surgery may be performed to repair the hernia and reposition the stomach.
Major complications of esophageal surgery
Esophageal surgery is a significant procedure that carries various potential complications, which may occur during the operation, shortly after, or even in the long term. These complications can vary depending on the type of surgery performed, the patient’s overall health, and the surgical team’s expertise. Understanding these complications is crucial for effective preparation and early intervention, which helps minimize risks and promote a better recovery.
Complications during surgery
- Bleeding: Bleeding occurs during the separation of the esophagus from the surrounding tissue or during the connection, and its management depends on the speed of detection and surgical control.
- Injury to surrounding organs: Due to the proximity of the esophagus to the lungs, trachea, heart, and stomach, accidental injury to these organs may occur during esophagectomy or reconnection procedures.
- Cardiac arrhythmia: Due to the effect of surgery and anesthesia on the autonomic nervous system, this condition may require careful cardiac monitoring during the procedure.
Immediate postoperative complications
- Anastomotic Leak: One of the most serious complications occurs when the surgical reconnection of the esophagus to the stomach or intestinal segment does not heal, leading to fluid leakage into the chest or abdominal cavity, and may cause severe infection or septic shock.
- Infections: These may include wound infections or pneumonia, and are more likely to occur if immunity is compromised or there is a leak at the site of delivery.
- Difficulty breathing: As a result of fluid collection in the chest, pulmonary infiltration, or the effect of surgery on the diaphragm, which may require respiratory support or fluid drainage.
Long-term complications
- Stenosis at the site of the reconnection can be caused by irregular tissue healing, leading to narrowing of the duct and difficulty passing food, and may require endoscopic dilation or additional intervention.
- Gastroesophageal reflux: Due to the removal or modification of the natural valve between the esophagus and stomach, allowing acid to come back up, and may persist for long periods of time after the operation.
- Persistent swallowing difficulties: Due to structural or neurological changes after surgery, and may require modification of eating patterns or rehabilitative therapies.
- Excessive weight loss and malnutrition: Due to reduced ability to eat or absorb food, requiring careful nutritional monitoring and replacement of essential elements.

Factors that increase the risk of esophageal surgery complications
The likelihood of developing esophageal surgery complications is influenced by various health and behavioral factors that can impact the body’s recovery ability. It is essential to consider these factors when evaluating a patient before surgery, as they can increase the risk of problems occurring during or after the procedure. This necessitates careful preparation and diligent follow-up. The most important of these factors include:
- Old age: The older the patient, the higher the risk of complications from esophageal surgery due to impaired vital functions, decreased tissue healing ability, and increased anesthetic risks.
- Presence of chronic diseases (such as diabetes, heart disease, or lung disease): These conditions reduce the body’s ability to adapt to surgery and increase the risk of infection, poor blood perfusion, or impaired breathing, which can lead to worsening of esophageal surgery complications after the procedure.
- Weakened immunity: Whether due to immunosuppressive medications or chronic diseases, a poor response to infection raises the risk of serious infections and site leakage, one of the most common acute complications of esophageal surgery.
- Smoking: It negatively affects blood perfusion and the body’s ability to heal and increases the risk of surgical site leakages and post-operative lung infections.
- Malnutrition before surgery: A lack of proteins and essential elements impairs wound healing and reduces the body’s resistance to complications, such as infection or severe weight loss, after surgery.
How are complications diagnosed and treated?
After esophageal surgery, some patients may encounter complications that differ in both nature and severity. Early detection of these post-operative complications is essential for optimizing recovery and preventing deterioration. The medical team employs a variety of accurate diagnostic methods to identify the types of complications that can arise from esophageal surgery. This helps them develop a tailored treatment plan for each case. Diagnostic techniques may include advanced imaging, endoscopy, and, when necessary, additional medical or surgical interventions. This comprehensive approach ensures the safe and effective management of any complications that may occur.
The role of medical imaging (X-rays – CT scan)
When a complication of esophageal surgery is suspected, dye radiography is one of the first procedures to be used, especially to assess the presence of leakage at the surgical site. In this test, the patient is asked to swallow a contrast material and its path through the esophagus and stomach is monitored to detect any leakage outside the normal course. In cases where the patient has an unexplained fever, difficulty breathing, or chest pain after the procedure, a computerized tomography (CT scan) is used because it provides us with accurate images that show the accumulation of fluid or abnormal air within the chest or abdominal cavity, which are important indicators of leakage or inflammation.
Endoscopy to detect a leak or stenosis
Endoscopy remains a vital tool in assessing esophageal surgery complications, particularly when leaks are suspected but not evident on imaging, or when persistent swallowing difficulties suggest esophageal narrowing. By inserting a flexible scope through the mouth, physicians can closely examine the surgical anastomosis and evaluate the condition of the esophagogastric mucosa. This technique enables direct visualization of subtle leaks, ulcerations, or localized inflammation.
In cases of stenosis resulting from irregular healing or fibrotic scarring—common esophageal surgery complications—endoscopy allows for immediate therapeutic dilation using balloons or specialized instruments, helping restore swallowing function and enhance patient quality of life. Additionally, endoscopic placement of stents is employed to seal leakage sites or maintain luminal patency, especially in patients unresponsive to pharmacologic treatment alone.
Medical or surgical treatment depending on the situation
Management of esophageal surgery complications depends on the type, severity, and the patient’s overall clinical response. When a minor anastomotic leak occurs without signs of severe infection, conservative measures such as withholding oral intake, administering broad-spectrum antibiotics, and providing parenteral nutrition or enteral feeding via a specialized tube may suffice. However, if the leak is extensive or associated with abscess formation or sepsis, surgical intervention is often required to repair the defect or place drainage tubes.
Strictures that develop weeks or months after surgery represent another form of esophageal surgery complications and are typically managed with repeated endoscopic dilatation sessions tailored to the patient’s response. Late-onset GERD is treated pharmacologically using acid-suppressing agents and motility enhancers, alongside long-term dietary adjustments. In all scenarios, addressing esophageal surgery complications demands close medical supervision and a personalized treatment strategy to maintain stability and optimize outcomes.
Do complications differ between open and laparoscopic surgery?
The nature and rate of esophageal surgery complications vary depending on the surgical technique employed, whether traditional open surgery or minimally invasive laparoscopic procedures. Open surgery involves a large incision in the chest or abdomen and is typically linked to higher rates of esophageal surgery complications, including infections, significant blood loss, delayed wound healing, and post-operative respiratory issues. Research indicates that serious complication rates in open surgery may range from 40% to 60%, influenced by the patient’s overall health.
Conversely, laparoscopic surgery is associated with reduced rates of certain esophageal surgery complications, particularly those related to pulmonary injury and wound infection. It also shortens hospital stays and accelerates recovery, though it still carries risks such as anastomotic leakage or stricture formation, albeit less frequently. Selecting the appropriate surgical approach requires a thorough assessment of the patient’s condition, disease severity, and the surgeon’s expertise.
Why is laparoscopic surgery preferred in some cases?
Laparoscopic surgery is preferred in many cases due to the lower rate of some complications of esophageal surgery compared to open surgery and being less damaging to surrounding tissues, this type of surgery reduces the need for large incisions, which contributes to less postoperative pain, lower risk of infections, and faster functional recovery of the patient. It is also a good option for elderly or chronically ill patients as laparoscopic surgery reduces the overall surgical burden and improves the chances of early discharge from the hospital without affecting long-term outcomes.
Preventing complications of esophageal surgery
Preventing complications of esophageal surgery depends on a series of careful procedures that begin before and continue after the operation to ensure the best possible results, one of the most important factors affecting the minimization of these complications:
Choosing the right surgeon and center
Performing surgery in hospitals with high expertise and a specialized surgical team is directly associated with a lower rate of esophageal surgery complications and higher success rates, due to the integration of surgical and nursing care and the accuracy of preparation and follow-up protocols. high expertise and a specialized surgical team is directly associated with a lower rate of esophageal surgery complications and higher success rates, due to the integration of surgical and nursing care and the accuracy of preparation and follow-up protocols.
Prepare the patient well before the procedure
This includes assessing the patient’s general condition, treating malnutrition, managing chronic diseases such as diabetes or heart disease, and quitting smoking. This preparation helps minimize the risk of infection, wound healing issues, and respiratory complications.
Stick to your post-surgery plan
The plan includes gradually consuming fluids and pureed food, adhering to medications, and avoiding strenuous activities during the recovery period. Adhering to this plan is important to minimize the chances of suture site leakage or severe reflux.
Continuous medical follow-up
Regular follow-up with the medical team is essential to detect any early signs of esophageal surgery complications such as stenosis, inflammation, or swallowing difficulties, as these frequent check-ups help us intervene early and adjust the treatment plan if needed.
Esophageal surgery is a necessary treatment step in some complex cases, but its success is not complete without the patient’s awareness of how to prevent potential side effects. By choosing a specialized center, being well-prepared, and strictly adhering to the recovery plan, the risk of complications can be reduced. The risk of esophageal surgery complications can be significantly reduced, and an effective recovery that preserves digestive function and quality of life in the long term can be achieved.
Sources:
- Hashemi, S., & Bremner, R. M. (2015). Complications following surgery for gastroesophageal reflux disease and achalasia. Thoracic Surgery Clinics, 25(4), 485-498.
- MedlinePlus. (n.d.). Esophagectomy. U.S. National Library of Medicine.
