Ovarian injection with stem cells is one of the most significant recent advances in treating women’s fertility challenges, offering a modern approach to enhancing ovarian function and safely increasing the chances of pregnancy. Bimaristan Turkey Medical Center provides this treatment at a high standard and at competitive prices. In this article, we will cover everything you need to know about ovarian injection with stem cells.
The role of stem cells in treating infertility by improving ovarian function
During each menstrual cycle, the ovary releases a mature egg ready for fertilization. If the egg is not fertilized by the husband’s sperm, the body discards it, leading to a gradual decrease in the number of remaining eggs, known as the ovarian reserve. Some women experience an early decline in ovarian reserve, causing what is known as premature menopause or primary ovarian insufficiency. This issue is further complicated in women who marry late, as the lack of reserve negatively affects fertility and increases the likelihood of infertility in women.
Ovarian injection with stem cells
Ovarian injection with stem cells is one of the most promising new treatments for women in this category, as it contributes to:
- Increase the number of remaining follicles and stimulate them to grow
- Restoration of ovulatory function in women with early menopause
- Improved chances of pregnancy, especially when combined with ovulation-inducing medications
After injections, doctors often advise waiting three months before resorting to assisted fertilization methods such as IVF to ensure maximum benefit from the treatment.
We must differentiate between the quantity and quality of eggs, as some women have a low egg supply but excellent egg quality, and their fertility remains good, while others may have a large egg supply but poor egg quality, resulting in a lower chance of pregnancy. Experiments have shown that combining stem cells with intra-ovarian platelet-rich plasma injections can further improve:
- Egg quality
- Ovarian perfusion
- Cell regeneration and growth factor stimulation thanks to bioproteins
Not only can stem cells be injected into the ovary, but stem cells can also be injected into the endometrium to help:
- Achieving greater stability for the pregnancy during its early stages
- Endometrial regeneration
- Enhanced chances of implantation
Mechanism of ovarian injection with stem cells
Ovarian injection with stem cells is usually performed 5 days after the end of menstruation. The procedure takes only about one hour and is low-risk because the transplanted cells are taken from the woman’s own body. There are several steps that need to be followed for proper Ovarian injection with stem cells:
- Choosing a mesenchymal stem cell source that can be isolated from:
- Bone marrow (the most common source)
- Adipose tissue (harvested via simple liposuction)
- Peripheral blood (rarely used, following stimulation with G-CSF)
- Umbilical cord or placenta (the least utilized source, for ethical reasons)
- The isolation and preparation of cells in the laboratory, where they are cultured for a short time, while ensuring that they do not become cancerous or undifferentiated. The preparation process includes techniques such as:
- Centrifugation
- Cellular centrifugation
- Selective growth media
- Ovarian stimulation before injection with mild hormones or a low-intensity laser to optimize the ovarian environment
- The injection is usually done in the ovarian cortex, which is the layer that contains the primordial follicles
- Ovarian injection with stem cells aims to:
- Stimulation and activation of stem cells within dormant follicles
- Release of growth factors (such as IGF, VEGF, and EGF) by stem cells, leading to improved blood supply and cellular environment
- Injection techniques include:
- Transvaginal ultrasound, which is the most common method
- Laparoscopy, which is more accurate but more invasive
- Ovarian injection with stem cells aims to:
- Post-injection follow-up including
- Conducting periodic tests after injection to:
- AMH (Anti-Müllerian Hormone)
- FSH and LH
- Estradiol
- Monitoring the menstrual cycle and the appearance of ovulation signs
- If indicators improve, it is possible to:
- Ovarian stimulation to induce ovulation
- Immediately undergoing an IVF cycle
- Conducting periodic tests after injection to:
Stem cells do not turn into eggs or produce new ones; rather, they release biological signals that activate dormant follicles and secrete growth factors and antioxidants that regenerate damaged blood vessels and tissues, reduce inflammation, and improve the ovarian microenvironment.
Benefits of ovarian injection with stem cells
Ovarian injection with stem cells offers many benefits and advantages, including:
- Improved reproductive chances with no significant risks
- Stem cell injections improve the quality of eggs produced from the ovaries
- Safe, minimally invasive procedure
- Stem cells are extracted from the patient’s own body without the need for a donor
- Achieving menstrual cycle regularity
- Endometrial regeneration
- Increased secretion of female hormones (estrogen) from the ovaries
Keep in mind that the results of ovarian injection with stem cells vary from one woman to another, as the effectiveness of the treatment depends on several factors, including the main cause of infertility, the quality and quantity of the injected stem cells, and the approach used for injection. It is necessary to select patients carefully because stem cells are not suitable for all women and are used only in specific cases.
Ovarian injection with stem cells conditions
The prerequisites for ovarian injection with stem cells are as follows:
- Ruling out other causes of infertility that have nothing to do with the ovaries
- The woman does not have complete ovarian failure
- Age less than 40 years old
- The patient’s menstrual cycle is not interrupted
- Making sure the infertility is not caused by the husband
- Not taking cell-killing drugs, such as chemotherapy, for cancer patients
- No uterine abnormalities such as endometriosis or fibroids
The doctor must evaluate the case in detail to determine the patient’s readiness for the procedure. If the cause of infertility is due to a blockage in the reproductive tract, then Intruterine insemination (IUI) can be performed.
Ovarian injection with stem cells success rate
According to studies, this treatment improves egg quality by up to 67%, and a recent study indicated that ovarian injection with stem cells contributes significantly to the treatment of infertility caused by Asherman’s syndrome.
Risks and side effects of ovarian injection with stem cells
Ovarian injection with stem cells is a largely safe procedure, but any medical intervention is not without the possibility of side effects, including:
- Mild pain or discomfort during the injection
- Hyperthermia
- Bleeding
- Pressure drop
The cost of ovarian injection with stem cells in Turkey
Turkey is one of the leading countries that provides ovarian stem cell injection technology. Bimaristan Medical Center offers this procedure as part of an integrated package that includes hormonal evaluation, extraction and preparation of stem cells, injection using precise techniques, medical stay, and post-treatment follow-up, under the supervision of a specialized medical team and in accordance with the latest approved protocols.
| State | Cost in dollars (USD) | Notes |
|---|---|---|
| Turkey | 4,300 – 7,000 | All-inclusive packages (procedure + accommodation + transportation), low cost with high expertise |
| Spain | 5,200 – 7,000 | Advanced technology, price includes partial services, and may not cover all follow-up |
| Germany | 6,000 – 15,000 | Advanced research centers and quality services, but the cost is much higher |
| France | 7,000 – 16,000 | The health system is of high quality, but the price often includes only the procedure |
| United States | 15,000 – 25,000 | The most expensive option, excellent services, but the cost does not include accommodation or often follow-up |
| Canada | 15,000 – 22,000 | Similar to America in terms of quality and high cost, with no additional accompanying services |
It is not necessary to order all the services listed above; you can contact us to select the service you want and inquire about the details and cost.
Ovarian injection with stem cells is an advanced and convenient option for women looking for advanced treatment solutions to enhance fertility. At Bimaristan Medical Center, we guarantee comprehensive care with the latest technology and a specialized medical team. We encourage you to reach out to us to discover more about this procedure and understand how we can assist you in achieving your reproductive goals.
Sources:
- GenCell Clinic. (n.d.). Infertility. Diminished ovarian reserve in woman. Retrieved July 22, 2025
- Wei, D., Chen, Y., Cui, Y., Li, L., Guo, Z., Wang, B., Guo, X., & Wu, M. (2024). Autologous bone marrow-derived stem cells improved ovarian reserve in women with premature ovarian insufficiency: A prospective non-randomized clinical trial. Journal of Ovarian Research, 17(1), Article 62.
